COILS/PCOILS

 
PCOILS compares a single sequence or a sequence alignment to a database of known coiled-coils and derives a similarity score. The program then calculates the probability that the sequence will adopt a coiled-coil conformation. The older COILS version can be found here.
 

Input

Enter sequence or sequence alignment
or upload a local file
Select alignment format
 

Options

Input mode
 No alignment (only single sequence)   Run PSI-BLAST   Use input alignment  
Weighting
 yes   no  
Matrix
 MTIDK matrix   PDB matrix   Iterated matrix   MTK matrix  
Run PSIPRED
 

Job Options

Job-ID
 (leave empty for automatic creation)
Send notification to (optional)
 

 
 
Lupas, A., Van Dyke, M., and Stock, J. (1991) Predicting coiled coils from protein sequences. Science, 252, 1162-1164. Free Abstract

Lupas, A. (1996) Prediction and analysis of coiled-coil structures. Methods Enzymol., 266, 513-525.

Parry, DA. (1982) Coiled-coils in alpha-helix-containing proteins: analysis of the residue types within the heptad repeat and the use of these data in the prediction of coiled-coils in other proteins. Biosci. Rep., 2, 1017-1024. Free Abstract