This server compares a single sequence (COILS) or a sequence alignment (PCOILS) to a database of known coiled-coils and derives a similarity score. The program then calculates the probability that the sequence will adopt a coiled-coil conformation. The external COILS server at ISREC can be found here.


or upload a local file
Select alignment format
Predict coiled-coil regions in human Myosin. Paste example sequence.


Input mode
 No alignment (only single sequence)   Run PSI-BLAST   Use input alignment  
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 MTIDK matrix   PDB matrix   Iterated matrix   MTK matrix  

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Lupas, A., Van Dyke, M., and Stock, J. (1991) Predicting coiled coils from protein sequences. Science, 252, 1162-1164. Free Abstract

Lupas, A. (1996) Prediction and analysis of coiled-coil structures. Methods Enzymol., 266, 513-525.

Parry, DA. (1982) Coiled-coils in alpha-helix-containing proteins: analysis of the residue types within the heptad repeat and the use of these data in the prediction of coiled-coils in other proteins. Biosci. Rep., 2, 1017-1024. Free Abstract