Predict functional regions for viral DNA-ligase alignment.
If your input sequence is longer than 800 residues, please consider splitting it into domains or smaller overlapping segments. Since FRpred is resource intensive, please avoid submitting more than four jobs at a time.
or upload a local file
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 single FASTA sequence   alignment  
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References (please cite as appropriate)

Alva V., Nam SZ., Söding J., Lupas AN. (2016) The MPI bioinformatics Toolkit as an integrative platform for advanced protein sequence and structure analysis. Nucleic Acids Res. pii: gkw348. [Epub ahead of print] PMID: 27131380
Fischer JD., Mayer CE., Söding J. (2008) Prediction of Protein Functional Residues From Sequence by Probability Density Estimation. Bioinformatics 24:613-620. PMID: 18174181
Mihalek I., Res I., Lichtarge O. (2004) A Family of Evolution-Entropy Hybrid Methods for Ranking Protein Residues by Importance. J Mol Biol 336:1265-1282. PMID: 15037084
Hannenhalli SS., Russel, RB. (2000) Analysis and Prediction of Functional Sub-types from Protein Sequence Alignments. J Mol Biol 303(1):61-76. PMID: 11021970
Altschul S., Madden T., Schaffer A., Zhang J., Zhang Z., Miller W., Lipman D. (1997) Gapped BLAST and PSI-BLAST: a New Generation of Protein Database Search Programs. Nucl Acids Res 25:3389-3402. PMID: 9254694
Kabsch W., Sander C. (1983) Dictionary of Protein Secondary Structure: Pattern Recognition of Hydrogen-Bonded and Geometrical Features. Biopolymers 22:2577-2637. PMID: 6667333
Adamczak R., Porollo A., Meller J. (2004) Accurate Predicition of Solvent Accessibility Using Neural Networks-Based Regression. Proteins 56:753-767. PMID: 15281128


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