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HHpred - Homology detection & structure prediction by HMM-HMM comparison

Search with pancreatitis induced protein PIP49.
or upload a local file
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Select HMM databases
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MSA Generation Method
 HHblits  Psiblast 
Score secondary structure
 yes  no  predicted vs predicted only 
Alignment mode
 local  global 
 (leave empty for automatic creation)
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Alva V., Nam SZ., Söding J., Lupas AN. (2016) The MPI bioinformatics Toolkit as an integrative platform for advanced protein sequence and structure analysis. Nucleic Acids Res. pii: gkw348. [Epub ahead of print] PMID: 27131380
Söding J., Biegert A., Lupas AN. (2005) The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res 33 (Web Server issue), W244-W248. PMID: 15980461
Söding J. (2005) Protein homology detection by HMM-HMM comparison. Bioinformatics 21: 951-960. PMID: 15531603
Hildebrand A., Remmert A., Biegert A., Söding J. (2009) Fast and accurate automatic structure prediction with HHpred. Proteins 77(Suppl 9):128-32. doi: 10.1002/prot.22499. PMID: 19626712
Meier A., Söding J. (2015) Automatic Prediction of Protein 3D Structures by Probabilistic Multi-template Homology Modeling. PLoS Comput Biol. 11(10):e1004343. doi: 10.1371/journal.pcbi.1004343. PMID: 26496371
Remmert M., Biegert A., Hauser A., Söding J. (2011) HHblits: Lightning-fast iterative protein sequence searching by HMM-HMM alignment. Nat Methods. 9(2):173-5. doi: 10.1038/nmeth.1818. PMID: 22198341