This server compares a single sequence (COILS) or a sequence alignment (PCOILS) to a database of known coiled-coils and derives a similarity score.


Predict coiled-coil regions in human Myosin.
or upload a local file
Select alignment format


Input mode
 No alignment (only single sequence)   Run PSI-BLAST   Use input alignment  
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 MTIDK matrix   PDB matrix   Iterated matrix   MTK matrix  

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References (please cite as appropriate)

Alva V., Nam SZ., Söding J., Lupas AN. (2016) The MPI bioinformatics Toolkit as an integrative platform for advanced protein sequence and structure analysis. Nucleic Acids Res. pii: gkw348. [Epub ahead of print] PMID: 27131380
Lupas A., Van Dyke M., Stock J. (1991) Predicting Coiled Coils from Protein Sequences. Science 252:1162-1164. PMID: 2031185
Lupas A. (1996) Prediction and Analysis of Coiled-Coil Structures. Methods Enzymol 266:513-525. PMID: 8743703
Parry DA. (1982) Coiled-Coils in Alpha-Helix-Containing Proteins: Analysis of the Residue Types within the Heptad
Repeat and the Use of These Data in the Prediction of Coiled-Coils in Other Proteins.
Biosci Rep 2(12):1017-24. PMID: 7165792


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